Increased sympathetic activity in rats submitted to chronic intermittent hypoxia
نویسندگان
چکیده
منابع مشابه
Medullary respiratory network drives sympathetic overactivity and hypertension in rats submitted to chronic intermittent hypoxia.
H ypertension is a pathological condition affecting up to one third of adult population worldwide. 1 Over the last few decades, the remarkable progress of the pharmacological antihypertensive therapies, such as β-adrenergic block-ers, angiotensin-converting enzyme inhibitors, angiotensin II receptor type 1 antagonists, and diuretics, combined with physical activities and dietary orientations, c...
متن کاملChronic intermittent hypoxia increases sympathetic responsiveness to hypoxia and hypercapnia.
We sought to determine whether chronic exposure to intermittent hypoxia (CIH) increases sympathetic responsiveness to subsequent chemoreflex stimulation. Sprague-Dawley rats were exposed to 30 days of CIH: exposure chamber %O2 [fractional concentration of chamber O2 (FcO2)] nadir 6.5-7% with return to 21% each minute for 8 h/day during the diurnal sleep period (Exp group). Sham controls (SC gro...
متن کاملRespiratory Network Enhances the Sympathoinhibitory Component of Baroreflex of Rats Submitted to Chronic Intermittent Hypoxia.
Chronic intermittent hypoxia (CIH) produces respiratory-related sympathetic overactivity and hypertension in rats. In this study, we tested the hypothesis that the enhanced central respiratory modulation of sympathetic activity after CIH also decreases the sympathoinhibitory component of baroreflex of rats, which may contribute to the development of hypertension. Wistar rats were exposed to CIH...
متن کاملThe Nervous Mechanism of Sympathetic over Activity Induced by Chronic Intermittent Hypoxia
Hypertension is concerned to be a common complication in Chronic Intermittent Hypoxia (CIH) conditions which mimic the state of Obstructive Sleep Apnoea (OSA) in clinic. Sympathoexcitation is a crucial origin in the process of high blood pressure and the mechanisms involved in the sympathoexicitatory changes after CIH exposure are complex referring to chemoreflex, baroreflex, neurotransmitters,...
متن کاملValidation of Housekeeping Genes in the Brains of Rats Submitted to Chronic Intermittent Hypoxia, a Sleep Apnea Model
Obstructive sleep apnea (OSA) is a syndrome characterized by intermittent nocturnal hypoxia, sleep fragmentation, hypercapnia and respiratory effort, and it has been associated with several complications, such as diabetes, hypertension and obesity. Quantitative real-time PCR has been performed in previous OSA-related studies; however, these studies were not validated using proper reference gene...
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ژورنال
عنوان ژورنال: Experimental Physiology
سال: 2007
ISSN: 0958-0670
DOI: 10.1113/expphysiol.2006.035501